Chelating Tendencies of Bioactive Aminophosphonates
نویسندگان
چکیده
منابع مشابه
Chelating Tendencies of Bioactive Aminophosphonates
The metal-binding abilities of a wide variety of bioactive aminophosphonates, from the simple aminoethanephosphonic acids to the rather large macrocyclic polyaza derivatives, are discussed with special emphasis on a comparison of the analogous carboxylic acid and phosphonic acid systems. Examples are given of the biological importance of metal ion - aminophosphonate interactions in living syste...
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Copper ions in the active sites of several proteins/enzymes interact with phenols and quinones, and this interaction is associated to the reactivity of the enzymes. In this study the speciation of the Cu(2+) with iminodiacetic phenolate/hydroquinonate ligands has been examined by pH-potentiometry. The results reveal that the iminodiacetic phenol ligand forms mononuclear complexes with Cu(2+) at...
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Xenobiotic exposure may induce cell membrane injury which would affect cellular structures and function. This study examined the influence of new aminophosphonates, synthesized for agrochemical application, on biological and model membranes properties. The aminophosphonates differed in the substituents on their carbon, nitrogen and phosphorus atoms. Measurements were made of the stability of pl...
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The antioxidative activity of some newly synthesized aminomethanephosphonic acid derivatives was studied. The compounds studied differed in their polarity and the hydrophobicity of the electronic substituents at their nitrogen and phosphorus atoms. It was found that all the aminophosphonates studied, both cyclic and acyclic, protected erythrocyte membranes against peroxidation to some extent. T...
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ژورنال
عنوان ژورنال: Metal-Based Drugs
سال: 1994
ISSN: 0793-0291
DOI: 10.1155/mbd.1994.247